Rabbit nasal cavities were assessed for responsiveness to ivacaftor in vivo (by nasal potential difference assay). ![]() Our objective in this study was to evaluate whether ivacaftor reverses the consequences of Pseudomonas aeruginosa–induced acquired cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction. As an experimental epithelium, rabbit tissue provides an excellent representation of human sinus disease, and the rabbit sinusitis model is both established and well suited for therapeutic interventions in vivo. ![]() Abnormal chloride (Cl –) transport dehydrates airway surface liquid (ASL) in sinonasal epithelium leading to mucus stasis and chronic rhinosinusitis.
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